Preservation technique for marginal livers prevents biliary stricture
Dr. Markus Selzner, CNTRP Project 1 Researcher, published new research showing that a preservation technique known as sequential subnormothermic ex vivo liver perfusion (SNEVLP) prevents ischemic type biliary stricture following liver transplantation using grafts from donations after cardiac death (DCD). Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that the preservation of DCD grafts using SNEVLP versus cold storage reduces bile duct and endothelial cell injury post transplantation.
"While the use of marginal livers for transplantation has increased the donor pool, it is not without issue," explains Dr. Selzner. "Preservation techniques, such as cold storage, are not well tolerated by marginal livers and can cause reperfusion or graft dysfunction. This has prompted our investigation of preservation methods that avoid the negative effects of cooling." READ MORE
"Subnormothermic Ex Vivo Liver Perfusion Reduces Endothelial Cell and Bile Duct Injury after DCD Pig Liver Transplantation." Jan M. Knaak, Vinzent N. Spetzler, Nicolas Goldaracena, Markus U. Boehnert, Fateh Bazerbachi, Kristine S. Louis, Oyedele A. Adeyi, Leonid Minkovich, Paul M. Yip, Shaf Keshavjee, Gary A. Levy, David R. Grant, Nazia Selzner and Markus Selzner. Liver Transplantation; DOI: 10.1002/lt.23986