• David Hartell

Presence of diabetes autoantigens in extracellular vesicles derived from human islets - new CNTRP Pr


A team of researchers from CNTRP Project 3, led by Dr. Steven Paraskevas, describe a new understanding of the progression of type 1 diabetes by showing the presence of diabetes auto antigens in natural extracellular vesicles derived in isolated human islet cells. In a publication recently published in Nature Scientific Reports, the team that includes CNTRP Trainee Craig Hasilo and Alissa Rutman, shows the production of extracellular vesicles by normal, nondiabetic human islets following isolation and the presence of type 1 diabetes autoantigens in these extracellular particles.

This work is a collaboration between CNTRP researchers across institutions working within our Project 3: Understanding, predicting and preventing early graft rejection and GVHD

Craig P. Hasilo, Sarita Negi, Isabelle Allaeys, Nathalie Cloutier, Alissa K. Rutman, Marco Gasparrini, Éric Bonneil, Pierre Thibault, Éric Boilard & Steven Paraskevas. Presence of diabetes autoantigensin extracellular vesicles derivedfrom human islets. Scientific RepoRts | 7: 5000 | DOI:10.1038/s41598-017-04977-y


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